[Source: AnimeNewsNetwork] Fūka Koshiba (Iki mo Dekinai Natsu) plays the title witch girl Kiki in the film. 16-year-old actor Ryōhei Hirota performs the critical role of Kiki's friend Tombo. Co-starring with Koshiba and Hirota is Machiko Ono (Suzaku, Like Father, Like Son) as Osono, the owner of the bakery where Kiki works. Hiroshi Yamamoto plays Osono's baker husband Fukuo, and Miho Kanazawa plays a woman named Saki who visits the bakery. Rie Miyazawa (Oceans, Hana, Peony Pavilion) plays Kiki's mother Kokiri, and Michitaka Tsutsui (Reunion, Ballad: Namonaki Koi no Uta, Shikoku) plays Kiki's father Okino. Additionally, Tadanobu Asano (Ichi the Killer, Lupin III) will play veterinarian Dr. Ishi.
Satoko Okudera (Summer Wars, Wolf Children, The Princess and the Pilot) has written the script for the film.